Recommended Storage Conditions (Post-Reconstitution)

Use Bacteriostatic Water for multi-dose vials: Tesamorelin (a GHRH analog) is typically supplied as a lyophilized powder, intended to be mixed with Bacteriostatic Water for Injection (0.9% benzyl alcohol) for multi-dose use.

Key Storage Parameters

  • Temperature: Refrigerate at 2–8°C (36–46°F) after reconstitution
  • Duration: Use within 21 days after reconstitution (per FDA-approved labeling for Egrifta SV)
  • Light protection: Keep in original carton; protect from light
  • Do not freeze reconstituted solution
  • Do not shake; gently swirl to mix

Reconstitution Procedure

  1. Remove the lyophilized vial and diluent vial from refrigerator; allow to reach room temperature (15-30 minutes)
  2. Clean vial stoppers with an alcohol swab
  3. Inject the specified volume of Bacteriostatic Water for Injection slowly down the vial wall
  4. Gently swirl (do not shake) until powder is completely dissolved
  5. Inspect visually: solution should be clear and colorless; discard if cloudy, discolored, or contains particles
  6. Label with date and time of reconstitution
  7. Refrigerate immediately; do not store at room temperature

Storage Comparison: Before vs. After Reconstitution

Parameter Lyophilized (Before Reconstitution) Reconstituted Solution
Temperature 2–8°C (refrigerator) or -20°C (freezer) 2–8°C (refrigerator only)
Maximum Storage Duration Until expiration date 21 days
Freeze? Yes (lyophilized) No
Light Sensitivity Protect from light Protect from light

Signs of Degradation

Discard reconstituted tesamorelin if you observe:

  • Cloudiness or turbidity in the solution
  • Visible particles or precipitate
  • Discoloration (should be clear and colorless)
  • Solution stored beyond 21 days after reconstitution
  • Solution that has been frozen after reconstitution

Temperature Excursions

If reconstituted tesamorelin is accidentally left at room temperature:

  • Brief exposure (less than a few hours) may be acceptable in some contexts
  • Prolonged room temperature exposure significantly reduces stability and should be avoided
  • When in doubt, discard and reconstitute a fresh vial

Disclaimer

This information is for educational and research purposes only. Tesamorelin is an FDA-approved medication (Egrifta SV) for specific medical conditions. All protocols described here reference the approved prescribing information. For any medical use, follow the prescribing physician’s instructions and official product labeling.