Retatrutide (10 mg Vial) Dosage Protocol
Quickstart Highlights
Retatrutide is a novel triple agonist targeting GLP-1, GIP, and glucagon receptors[1], studied for substantial weight loss and metabolic improvement in obesity and type 2 diabetes[2][3]. With an extended half-life of approximately 6 days, this peptide enables convenient once-weekly subcutaneous dosing with a gradual titration protocol to optimize tolerability[1][4].
- Reconstitute: Add 2.0 mL bacteriostatic water → 5.0 mg/mL concentration for convenient weekly doses.
- Typical weekly range: 2–12 mg once weekly (gradual escalation over 12+ weeks).
- Easy measuring: At 5.0 mg/mL, 1 unit = 0.01 mL ≈ 50 mcg on a U-100 insulin syringe.
- Storage: Lyophilized: freeze at −20 °C (−4 °F); after reconstitution, refrigerate at 2–8 °C (35.6–46.4 °F) and use within 2–4 weeks.
Dosing & Reconstitution Guide
Educational guide for reconstitution and weekly dosing
Standard / Gradual Titration Approach (2 mL = 5.0 mg/mL)
| Week(s) | Weekly Dose (mcg) (mg) | Units (per injection) (mL) |
|---|---|---|
| Weeks 1–4 | 2,000 mcg (2 mg) | 40 units (0.40 mL) |
| Weeks 5–8 | 4,000 mcg (4 mg) | 80 units (0.80 mL) |
| Weeks 9–12 | 8,000 mcg (8 mg) | 160 units (1.60 mL) — use 2 vials or split injection |
| Weeks 13+ | 12,000 mcg (12 mg) | 240 units (2.40 mL) — use 2 vials or split injection |
Frequency: Inject once weekly subcutaneously. This schedule follows clinical trial protocols that demonstrated significant weight loss (up to 24% at 48 weeks with 12 mg weekly)[2] while minimizing gastrointestinal adverse events through gradual escalation[1][4]. Starting at 2 mg weekly (versus 4 mg) significantly reduces initial GI side effects. For doses exceeding 1.0 mL, either reconstitute a second vial or split the dose into multiple injection sites.
Reconstitution Steps
- Draw 2.0 mL bacteriostatic water with a sterile syringe.
- Inject slowly down the vial wall; avoid foaming.
- Gently swirl/roll until dissolved (do not shake vigorously).
- Label with reconstitution date and refrigerate at 2–8 °C (35.6–46.4 °F), protected from light.
Note: The 10 mg vial size with 2.0 mL reconstitution provides excellent concentration (5.0 mg/mL) for convenient dosing. Lower weekly doses (2–4 mg) fit comfortably in a single syringe, while higher maintenance doses (8–12 mg) require multiple vials or split injections across different sites.
Supplies Needed
Plan based on a 12–48 week weekly protocol with gradual titration to maintenance dose.
- Peptide Vials (Retatrutide, 10 mg each): Requirements increase with dose escalation
- 12 weeks (2→4→8 mg titration): ~6 vials
- 24 weeks (up to 12 mg): ~20 vials
- 48 weeks (maintenance at 12 mg): ~49 vials
- Insulin Syringes (U-100, 1 mL):
- Per week: 1 syringe (once-weekly dosing)
- 12 weeks: 12 syringes
- 24 weeks: 24 syringes
- 48 weeks: 48 syringes
- Bacteriostatic Water (10 mL bottles): Use 2.0 mL per vial for reconstitution.
- 12 weeks (6 vials): 12 mL → 2 × 10 mL bottles
- 24 weeks (20 vials): 40 mL → 4 × 10 mL bottles
- 48 weeks (49 vials): 98 mL → 10 × 10 mL bottles
- Alcohol Swabs: One for the vial stopper + one for the injection site each week.
- Per week: 2 swabs
- 12 weeks: 24 swabs → 1 × 100-count box
- 24 weeks: 48 swabs → 1 × 100-count box
- 48 weeks: 96 swabs → 1 × 100-count box
Protocol Overview
Concise summary of the once-weekly regimen based on clinical trial protocols.
- Goal: Achieve substantial weight loss (up to 24% of body weight) and improved metabolic parameters through triple receptor agonism[2][5].
- Schedule: Weekly subcutaneous injections for 12+ weeks with gradual dose escalation.
- Dose Range: 2–12 mg once weekly; clinical trials tested up to 12 mg as the maximum maintenance dose[1][3].
- Reconstitution: 2.0 mL per 10 mg vial (5.0 mg/mL) provides excellent concentration for convenient weekly dosing.
- Storage: Lyophilized frozen at −20 °C (−4 °F); reconstituted solution refrigerated at 2–8 °C (35.6–46.4 °F); use within 2–4 weeks.
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