Retatrutide (5mg Vial) Dosage Protocol
Retatrutide (5 mg Vial) Dosage Protocol
Quickstart Highlights
Retatrutide is a novel triple agonist targeting GLP-1, GIP, and glucagon receptors, studied for substantial weight loss and metabolic improvement in obesity and type 2 diabetes. With an extended half-life of approximately 6 days, this peptide enables convenient once-weekly subcutaneous dosing with a gradual titration protocol to optimize tolerability.
- Reconstitute: Add 2.0 mL bacteriostatic water → 2.5 mg/mL concentration for practical weekly doses.
- Typical weekly range: 2–12 mg once weekly (gradual escalation over 12+ weeks).
- Easy measuring: At 2.5 mg/mL, 1 unit = 0.01 mL ≈ 25 mcg on a U-100 insulin syringe.
- Storage: Lyophilized: freeze at −20 °C (−4 °F); after reconstitution, refrigerate at 2–8 °C (35.6–46.4 °F) and use within 2–4 weeks.
Dosing & Reconstitution Guide
Standard / Gradual Titration Approach (2 mL = 2.5 mg/mL)
| Week(s) | Weekly Dose | Units (per injection) |
|---|---|---|
| Weeks 1–4 | 2,000 mcg (2 mg) | 80 units (0.80 mL) |
| Weeks 5–8 | 4,000 mcg (4 mg) | 160 units (1.60 mL) |
| Weeks 9–12 | 8,000 mcg (8 mg) | 320 units (3.20 mL) |
| Weeks 13+ | 12,000 mcg (12 mg) | 480 units (4.80 mL) |
Frequency: Inject once weekly subcutaneously.
Reconstitution Steps
- Draw 2.0 mL bacteriostatic water with a sterile syringe.
- Inject slowly down the vial wall; avoid foaming.
- Gently swirl/roll until dissolved (do not shake vigorously).
- Label with reconstitution date and refrigerate at 2–8 °C (35.6–46.4 °F), protected from light.
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